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Explanation

Timeline

Note: As I am primarily a show fan, feel free to email me any corrections. I probably missed something.

Comics

June 1963. The first Doom Patrol comic story featuring Larry Trainor/Negative Man, an Air Force test pilot fused to an alien negative spirit, is released. (My Greatest Adventure #80)
September 1977. After Larry Trainor's death, the Negative Spirit inside of him is transferred to Valentina Vostok of the Soviet Air Force. (Showcase vol 1 #94)
February 1989. The Negative Spirit, potentially known as Mercurius, originally thought to be a projection of Larry's consciousness, is revealed to be its own unique being. (Doom Patrol Vol 2 #19)
February 1989. The Negative Spirit, Larry Trainor, and Dr. Eleanor Poole merge to become a different being known as Rebis, who is not any of them. (Doom Patrol vol 2 #19)
December 2016. In Gerard Way's run of Doom Patrol, Larry's Negative Spirit is known as Keeg Bovo. He is introduced for the first time. This may or may not be the same individual as Mercurius. (Doom Patrol vol 6 #2) January 2017. Keeg Bovo takes Larry Trainor and Cliff Steele to his dimension, the Negative Space. (Doom Patrol vol 6 #4)
August 2019. Larry Trainor becomes Positive Man. (Weight of the Worlds #2)
July 2023. We learn that Keeg Bovo left Larry Trainor sometime after he became positive man. (Unstoppable Doom Patrol #4)

Live Action Adaptation

February 2019. The first episode of Doom Patrol, introducing Larry Trainor's live action/cgi Negative Spirit, premieres on DC Universe.
July 2020. Space Patrol airs and introduces Valentina Vostok, a one-episode character who has a Spirit of her own.
September 2021. The episode Vacay Patrol, season 3 episode 2, writes the Negative Spirit off. It tells Larry it wants to take him to space, but abandons him, leaving for its dimension and sending Larry back home.
October 2021. Keeg, the infant son of Larry Trainor and his Negative Spirit, is born.
December 2022. In the show, Larry Trainor travels to the future and sees an adult version of his son, Keeg, and his own ghost in a dystopian apocalypse as the final season premieres.
April 2023. In an adjacent universe, Titans, another DC show, has its own version of the Negative Spirit. This Spirit is an adult; however, as Larry's negative Spirit carries only signatures of blue, this Spirit carries both blue and red signatures, just as Larry's infant son does. It is unclear if this is the original Negative Spirit of Larry's or an adult version of Larry's son.
November 2023. Larry's Negative Spirit makes an appearance once more as Larry time travels back to 1996. The Spirit possesses past!Larry's body and speaks to present!Larry.
November 2023. Doom Patrol ends.

Contact
Agnes Alien
spirits@alien.hospital